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CRYSVITA treats

X-linked hypophosphatemia (XLH)
- Tumor-induced osteomalacia (TIO)

FIND A SPECIALIST STAY INFORMED

Receiving your prescription for CRYSVITA

Here’s what will happen once you’ve been approved to start CRYSVITA

Your specialty pharmacy will work with you to schedule a time for your or your child’s medication to be delivered. It’s important to pick up or accept the delivery on time and refrigerate it properly.

A nurse

NOTE: You must keep CRYSVITA vials in their original carton and store them in the refrigerator until it’s time to use them.

Two speech bubbles

Starting CRYSVITA may take time, but we’re here to help!

We know you’ll be ready to start treating your or your child’s XLH once you’ve been prescribed CRYSVITA. Waiting can be frustrating, but Kyowa Kirin is here to support you as you get started. Reach out to your Case Manager with questions about your or your child’s first dose. They can explain how to work with the specialty pharmacy and treatment site to set up appointments.

Don’t delay your or your child’s first dose of CRYSVITA

Remember, CRYSVITA must be administered by a healthcare professional. Your starting dose is unique to you because it is based on your weight.

Set up your or your child’s injection appointment promptly when you receive the medication.

If you or your child miss a dose, take the next prescribed dose of CRYSVITA as soon as possible. To avoid missed doses, CRYSVITA may be given up to 3 days before or after the scheduled treatment date.

Proper storage and handling of CRYSVITA

Once you have your medication at home, follow these instructions for storing and handling CRYSVITA:

CRYSVITA vials must be kept refrigerated at 36ºF to 46ºF (2ºC to 8ºC) in the original carton until it’s time to use them. Keep the CRYSVITA vial in the original carton to protect it from light until time of use
Do not freeze or shake CRYSVITA
Do not use CRYSVITA after the expiration date stamped on the carton
CRYSVITA vials are single dose only. Any unused product should be discarded

A refrigerator

If you have any questions about the storage and handling of CRYSVITA, contact your specialty pharmacy.

Understanding your treatment plan for CRYSVITA

Staying on CRYSVITA

Aly, a person living with XLH, standing and smiling while holding her purse

Indication

What is CRYSVITA?

CRYSVITA is a prescription medicine used to treat adults and children 6 months of age and older with X-linked hypophosphatemia (XLH).

What is CRYSVITA?

CRYSVITA is a prescription medicine used to treat adults and children 6 months of age and older with X-linked hypophosphatemia (XLH).

Important Safety Information

You should not take CRYSVITA if:

You take an oral phosphate supplement and/or a specific form of vitamin D supplement (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).
Your phosphorus levels from a blood sample are within or above the normal range for age.
You have kidney problems.

What is the most important information you should know about CRYSVITA?

Some patients developed allergic reactions (e.g., rash and hives) while taking CRYSVITA. Your doctor will monitor you for symptoms of an allergic reaction while you are taking CRYSVITA. Your treatment may need to be discontinued for serious allergic reactions.
High levels of phosphorus in the blood have been reported in some patients taking CRYSVITA. This may be related to a risk of high calcium levels in the kidneys. Your doctor will collect blood samples to monitor your levels. If you are already taking CRYSVITA, dose interruption and/or dose reduction may be required based on your serum phosphorus levels.
High levels of calcium in the blood have been reported in patients taking CRYSVITA. The risk is greater in patients with pre-existing hyperparathyroidism (overactive parathyroid glands), for those who are unable to move for extended periods of time, become dehydrated, have high vitamin D levels, or have kidney issues. If you are at greater risk, your doctor will monitor your blood calcium and parathyroid hormone levels before you start and while taking CRYSVITA. If you develop high levels of blood calcium, your doctor may need to stop your treatment until it is adequately managed.
Administration of CRYSVITA may result in reactions at the injection site, such as hives, reddening of the skin, rash, swelling, bruising, pain, severe itching of the skin, and collection of blood outside of a blood vessel (i.e., hematoma). Call your doctor if you develop an injection site reaction. CRYSVITA may be discontinued if severe injection site reactions occur.

What are the possible side effects of CRYSVITA?

Adverse reactions that were seen in children with XLH are:

Fever
Injection site reaction
Cough
Vomiting
Pain in arms and legs
Headache
Tooth abscess
Dental cavities

Diarrhea
Decreased vitamin D levels
Toothache
Constipation
Muscle pain
Rash
Dizziness
Nausea

Adverse reactions that were seen in adults with XLH are:

Back pain
Headache
Tooth infection
Restless legs syndrome
Decreased vitamin D levels

Dizziness
Constipation
Muscle spasms
Phosphorus levels increased in the blood

Narrowing of the spaces within the spine is common in adults with XLH, and pressure on the spinal cord has been reported in adults taking CRYSVITA. It is not known if taking CRYSVITA worsens the narrowing of the spaces within the spine or the pressure on the spinal cord.

Before taking CRYSVITA, tell your doctor about all of your medications (including supplements) and medical conditions, including if you:

Are taking oral phosphate and/or active vitamin D (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).
Are pregnant, think you may be pregnant, or plan to become pregnant. There is not enough experience to know if CRYSVITA may harm your unborn baby. Report pregnancies to the Kyowa Kirin, Inc. Adverse Event reporting line at 1-844-768-3544.
Are breastfeeding or plan to breastfeed. There is not enough experience to know if CRYSVITA passes into your breast milk. Talk with your doctor about the best way to feed your baby while you receive CRYSVITA.

While taking CRYSVITA, tell your doctor if you experience:

An allergic reaction such as rash or hives
A rash, swelling, bruising, or other reaction at the injection site
New or worsening restless legs syndrome

These are not all the possible side effects of CRYSVITA. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Kyowa Kirin, Inc. at 1-844-768-3544.

For important risk and use information, please see the full Prescribing Information for CRYSVITA.

What is CRYSVITA?

CRYSVITA is a prescription medicine used to treat adults and children 6 months of age and older with X-linked hypophosphatemia (XLH).

Important Safety Information

You should not take CRYSVITA if:

You take an oral phosphate supplement and/or a specific form of vitamin D supplement (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).
Your phosphorus levels from a blood sample are within or above the normal range for age.
You have kidney problems.

What is the most important information you should know about CRYSVITA?

Some patients developed allergic reactions (e.g., rash and hives) while taking CRYSVITA. Your doctor will monitor you for symptoms of an allergic reaction while you are taking CRYSVITA. Your treatment may need to be discontinued for serious allergic reactions.
High levels of phosphorus in the blood have been reported in some patients taking CRYSVITA. This may be related to a risk of high calcium levels in the kidneys. Your doctor will collect blood samples to monitor your levels. If you are already taking CRYSVITA, dose interruption and/or dose reduction may be required based on your serum phosphorus levels.
High levels of calcium in the blood have been reported in patients taking CRYSVITA. The risk is greater in patients with pre-existing hyperparathyroidism (overactive parathyroid glands), for those who are unable to move for extended periods of time, become dehydrated, have high vitamin D levels, or have kidney issues. If you are at greater risk, your doctor will monitor your blood calcium and parathyroid hormone levels before you start and while taking CRYSVITA. If you develop high levels of blood calcium, your doctor may need to stop your treatment until it is adequately managed.
Administration of CRYSVITA may result in reactions at the injection site, such as hives, reddening of the skin, rash, swelling, bruising, pain, severe itching of the skin, and collection of blood outside of a blood vessel (i.e., hematoma). Call your doctor if you develop an injection site reaction. CRYSVITA may be discontinued if severe injection site reactions occur.

What are the possible side effects of CRYSVITA?

Adverse reactions that were seen in children with XLH are:

Fever
Injection site reaction
Cough
Vomiting
Pain in arms and legs
Headache
Tooth abscess
Dental cavities

Diarrhea
Decreased vitamin D levels
Toothache
Constipation
Muscle pain
Rash
Dizziness
Nausea

Adverse reactions that were seen in adults with XLH are:

Back pain
Headache
Tooth infection
Restless legs syndrome
Decreased vitamin D levels

Dizziness
Constipation
Muscle spasms
Phosphorus levels increased in the blood

Narrowing of the spaces within the spine is common in adults with XLH, and pressure on the spinal cord has been reported in adults taking CRYSVITA. It is not known if taking CRYSVITA worsens the narrowing of the spaces within the spine or the pressure on the spinal cord.

Before taking CRYSVITA, tell your doctor about all of your medications (including supplements) and medical conditions, including if you:

Are taking oral phosphate and/or active vitamin D (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).
Are pregnant, think you may be pregnant, or plan to become pregnant. There is not enough experience to know if CRYSVITA may harm your unborn baby. Report pregnancies to the Kyowa Kirin, Inc. Adverse Event reporting line at 1-844-768-3544.
Are breastfeeding or plan to breastfeed. There is not enough experience to know if CRYSVITA passes into your breast milk. Talk with your doctor about the best way to feed your baby while you receive CRYSVITA.

While taking CRYSVITA, tell your doctor if you experience:

An allergic reaction such as rash or hives
A rash, swelling, bruising, or other reaction at the injection site
New or worsening restless legs syndrome

These are not all the possible side effects of CRYSVITA. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Kyowa Kirin, Inc. at 1-844-768-3544.

For important risk and use information, please see the full Prescribing Information for CRYSVITA.

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COMM-US-CRY-0929 June 2026